Can Cannabidiol Start where it Left Off for Epileptic Therapy?

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First off, what is Epilepsy? Answer :The enraged patterns of electrical activity in the human body can force the nervous system to cause Epileptic seizures that can range from mild to extremely aggressive. The intensity of the attack can be a significant factor in determining if the condition will breeze away or need immediate medical attention, which in most cases is required for sensory perturbations, convulsions, and unconsciousness. Why Epilepsy is classified as the most common neurological illness can be answered from thefigures as 0.7% of the global population is affected by it, where 200,000 are in Canada, whereas USA tops with more than 3 million patients.

Cannabis and its Use As Anti Epilepsy

Medication for people suffering from epilepsy such as the traditional antiepileptic drugs have managed to help 70% of the epileptic patients with the ability to hook off from pills and tablets after only a few years. For specific cases that have developed resistance to medication, electric stimulation therapies have been introduced that are quite annoying and painful for most patients. Those who reject the medication as well as electric stimulation interventions, they are more than happy to use cannabis as the treatment of their choice.

The use of Cannabis or Marijuana as a treatment for Epileptic patients dates back to 4000 BC where the first cases were reported. Documented ancient scripts have been recovered testifying the use of cannabis as medication for this disease, but for the 21st century, the evidence needs to be tangible and concrete for ordering themanufacturer to develop and market a drug based on Marijuana.

Cannabidiol (CBD)

Research on the use of cannabis has shown that Cannabidiol, one of the 113 active cannabinoids identified in cannabis is potent in anti-epileptic properties. Since research is still underway on this cannabinoid, there is little evidence that it can work as good on other similar cases of epileptic patients.

Epileptic cannabidiol

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Even to this day, people dispute its use given that only four studies have been published regarding the subject. Most of these studies involve only a small amount of candidates which were selected for the task. This means CBD has still some big shoes to fill when it comes to clinical testing, since most patients have never experienced any therapeutic effects while being under its influence.

The First Trial : CBD Wins

It goes back to the first trial of CBD being administered to a group of 9 epileptic patients. Out of the nine, four patients were set aside for 200 mg of CBD dosage, whereas the rest of the five were assigned placebos. After 3 months of treatment the results were somewhat convincing where 2 of the four  patients that were set to receive CBD reported no seizures, while the other five had simply no affect at all.

Second Trial : Signs of Recovery from CBD and Placebo

The second trial was initiated in 1980 on a group of 15 patients. These patients were selected carefully due to their one seizure a month condition. As done previously, the patients were divided into two groups from which half received placebo, whereas the other groupused 200 to 300mg of cannabidiol. In due course, the experiment concluded with 4 patients from cannabidiol and one from placebo stopped having seizures. The issue researchers faced in this experiment was that one of the investigators was ignored while the rest were blinded which might have possibly hindered the quality of the experiment.

3rd and 4thTrial : Inconclusive

The third experiment was carried out in 1985 and involved 12 institutionalized patients that were again segmented into two groups of 6. One group was given CBD 300 mg for the starting week and 200 mg the rest of the 3 weeks while the second group was given placebo. The fourth experiment also used 12 patients but for a longer span of almost a year, where both groups switched treatment of CBD and placebo after 6 months. Unfortunately, the 3rd and 4th experimental trials are weakly documented and cannot reveal any evidence of therapeutic effects on any of the two treatments.

Trials Restart

The evidence from these trials are insufficient, however, the use of CBD has sparked the recommissioning of trials with more sophisticated tests thanks to modern technology. Besides, these four tests did prove that cannabidiol did not affect the mental capabilities of the patients or cause any long term or short term side effects. We are hopeful that CBD will change the course medical treatment against many diseases that cause electrical disturbances in the nervous system.

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